American Airlines offers a comprehensive cancellation policy for domestic flights, ensuring travelers have flexibility when their plans change. For most tickets, you can cancel your flight within 24 hours of booking to receive a full refund, provided the booking was made at least two days before departure. After the 24-hour window, cancellation fees may apply depending on the fare class. Basic Economy tickets are typically non-refundable, but in certain situations, such as flight changes or weather disruptions, you may qualify for a voucher or credit. Refundable tickets offer the most flexibility, allowing you to cancel at any time without penalties.